Articles

THE EFFECT OF PROSTAGLANDIN E₁ (PGE₁) ON THE PLASMA-LYMPH BARRIER OF THE HIND LIMB OF RABBITS AND ITS ANTAGONIZATION BY AESCIN AND LNDOMETHACIN

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Abstract

kg/min PGE₁ for 15 min increased the lymph flow by between 13% and 81% for up to 45 min after the infusion, as measured at the plasma-lymph barrier of the hind limbs of rabbits. The lymph flow normalized after 105 min. The ED₅₀ for PGE₁ 15 min after infusion was 19 ng/kg/min. PGE₁ did not influence the permeation of macromolecules (PVP, proteins) from plasma to lymph. With a dose of 50 ng/kg/min severe side-effects appeared. The dose of 25 ng/kg/min did not produce any haemodynamic effects.

Intravenous injections of 0.25 to 0.8 mg/kg of aescin or 2.5 to 20 mg/kg of indomethacin reduced the increased lymph flow, obtained by injecting 25 ng/kg/ min of PGE₁ by 45% to 92% and 13% to 68% respectively for up to 45 min after infusion of PGE₁. The dose of 20 mg/kg i.v. of indomethacin as compared with 10 mg/kg did not show an increased efficacy but resulted in severe side-effects. The ED₅₀ of aescin was 0.29 mg/kg i.v. and that of indomethacin 3.4 mg/kg i.v. 45 min after PGE₁ infusion.

According to these results both aescin and indomethacin had an antagonistic effect on the increased permeability of the plasma-lymph barrier of the hind limbs of rabbits induced by PGE₁.

How to Cite:

Rothkopf -lschebeck, M. & Vogel, G., (1980) “THE EFFECT OF PROSTAGLANDIN E₁ (PGE₁) ON THE PLASMA-LYMPH BARRIER OF THE HIND LIMB OF RABBITS AND ITS ANTAGONIZATION BY AESCIN AND LNDOMETHACIN”, Lymphology 13(1), 47-52.