ARACHIDONIC ACID METABOLITES OF HUMAN LYMPHATICS
- H Sinzinger
- J Kaliman
- E Mannheimer
Abstract
Human lymphatics convert exogenously added 14C-arachidonic acid into PGE2, PGF2alpha and the main metabolite 6-keto-PGF1alpha. Thromboxane formation is undetectable either by radiothinlayer-chromatography or by radioimmunology. These data confirm and extend our earlier findings indicating an important PGI2-synthetic mechanism in human lymphatics. Assuming that lymphatic contractility is regulated at least in part by thromboxane A2, we propose that this derivative of arachidonic acid derives from extralymphatic sources.
How to Cite:
Sinzinger, H. & Kaliman, J. & Mannheimer, E., (1984) “ARACHIDONIC ACID METABOLITES OF HUMAN LYMPHATICS”, Lymphology 17(2), 39-42.
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