CYSTIC HYGROMA RECONSIDERED: HAMARTOMA OR NEOPLASM? PRIMARY CULTURE OF AN ENDOTHELIAL CELL LINE FROM A MASSIVE CERVICOMEDIASTINAL HYGROMA WITH BONY LYMPHANGIOMATOSIS
- CA Bowman
- MH Witte
- CL Witte
- DL Way
- RB Nagle
- JG Copeland
- CC Daschbach
Abstract
A young woman presented with massive enlargement of a giant cervicomediastinal cystic hygroma, which communicated in part with the thoracic duct and was associated with generalized bony lymphangiomatosis. Modern imaging and sophisticated intraoperative physiologic monitoring made one-stage resection feasible. Tissue culture of explants of the hygroma yielded a primary endothelial cell line still surviving after 18 months, which, like the cyst-lining endothelium in the original resected specimen, reacted positively for Factor VIII-associated antigen. These findings, in conjunction with the histologic picture, support the notion that cystic hygroma represents an expanding proliferating endothelial growth process and not simply a sequestered lymphatic receptacle.
How to Cite:
Bowman, C. & Witte, M. & Witte, C. & Way, D. & Nagle, R. & Copeland, J. & Daschbach, C., (1984) “CYSTIC HYGROMA RECONSIDERED: HAMARTOMA OR NEOPLASM? PRIMARY CULTURE OF AN ENDOTHELIAL CELL LINE FROM A MASSIVE CERVICOMEDIASTINAL HYGROMA WITH BONY LYMPHANGIOMATOSIS”, Lymphology 17(1), 15-22.
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